Catechol-O-methyltransferase (COMT) enzyme Catechol-O-methyltransferase (COMT) enzyme

An Overlooked

You may have the dopa decarboxylase (DDC) enzyme covered, but in Parkinson's disease there's another enzyme in the periphery that's interfering with levodopa's (L-dopa's) journey to the brain—and that's catechol-O-methyltransferase (COMT).1,2

Acts Out

Inhibiting the DDC enzyme may result in an increase in COMT enzyme activity, leading to more L-dopa metabolism.1-4

Multiple Paths
of Impact

Not only does the COMT enzyme metabolize L-dopa, but the resulting metabolite may also compete with L-dopa for transport to the brain.1,5