Parkinson's disease (PD) is a chronic, progressive, neurodegenerative disease1

In PD, early death of dopaminergic neurons in the substantia nigra pars compacta causes a dopamine deficiency in the basal ganglia. This may result in motor symptoms. PD is also associated with non-motor symptoms, and over the course of the disease both motor and non-motor symptoms typically progress, negatively impacting patients’ lives.1-5

As a slowly progressive disorder, PD may begin with non-motor symptoms, sometimes presenting more than a decade before motor symptoms appear or a diagnosis can be made. Currently, a universally adopted test for a definitive diagnosis in early stages of PD does not exist.2

see graphic+

Both motor and non-motor symptoms progress as the disease advances.2,6
*RBD=rapid eye movement sleep behavior disorder.

With an aging population, Parkinson's disease prevalence will continue to rise2,7,8

most common neurodegenerative disorder, with age as the dominant risk factor2,9,10

people in the US affected by Parkinson's disease8†

Lewin analyses of the 2011-2015 Medical Expenditure Panel Survey (MEPS), 2015 Medicare Current Beneficiary Survey (MCBS), and Census population projection for 2017.8

Parkinson’s disease can be a substantial burden not only for patients, but also for their caregivers2,11-13

As the disease progresses, patients may:

  • Experience non-motor symptoms, including anxiety disorders6,14
  • Be confronted with increasingly limiting physical disability15,16
  • Struggle to remain autonomous at home and may lose the ability to work17