Your patients rely on their levodopa (L-dopa), but enzymes interfere with its journey to the brain1-3

Enzymatic
Interference

L-dopa metabolism

(WITHOUT DDC ENZYME INHIBITION)

(WITH DDC ENZYME INHIBITION)

Dopa decarboxylase
(DDC) enzyme

Catechol-O-methyltransferase
(COMT) enzyme

L-dopa

DDC enzyme activity
In the periphery: metabolizes L-dopa into peripheral dopamine4,5

COMT enzyme activity
In the periphery: metabolizes L-dopa into 3-O-methyldopa (3-OMD)4,6 The metabolic activity of the COMT enzyme may increase when peripheral L-dopa inactivation is shifted from DDC to COMT1,7-9

Artistic depiction of L-dopa is provided for illustration purposes only.

references+