Artistic depiction is provided for illustration purposes only and is not a representation of exact molecular mechanism.
*LNAA transporter is the large neutral amino acid transport carrier system from the gut to the circulatory system, and from circulation to the brain.8
L-dopa may be metabolized by the COMT enzyme or may compete with 3-OMD for transport across the blood-brain barrier. This may result in only a small portion of each L-dopa dose reaching the brain.1,7,10
Any interference with the ability of L-dopa to reach the brain may impact its effect.1,4 A greater knowledge of enzymatic activity can help you focus on getting the most out of L-dopa.references+
EDS=excessive daytime sleepiness; MCI=mild cognitive impairment; RBD=rapid eye movement sleep behavior disorder.
Reprinted from The Lancet, Vol. 386, Kalia LV, Lang AE, Parkinson’s disease, Pages 896-912, Copyright (2015), with permission from Elsevier.